| 8/26/2017 | Stanford | 62 | vs | Rice | 7 | | Sydney AU | vs P12 |
| 8/31/2017 | Florida Intl | 17 | at | UCF | 61 | | | @ AAC |
| 9/1/2017 | UNC-Charlotte | 7 | at | Eastern Michigan | 24 | | | @ MAC |
| Navy | 42 | at | Florida Atlantic | 19 | | | AAC |
| 9/2/2017 | Alabama A&M | 7 | at | UAB | 38 | | | SWAC (1AA) |
| Northwestern State | 24 | at | Louisiana Tech | 52 | | | SLC (1AA) |
| Miami-Ohio | 26 | at | Marshall | 31 | | | MAC |
| Vanderbilt | 28 | at | Middle Tenn State | 6 | | | SEC |
| Lamar | 14 | at | North Texas | 59 | | | SLC (1AA) |
| UTEP | 7 | at | Oklahoma | 56 | | | @ B12 |
| Albany NY | 17 | at | Old Dominion | 31 | | | CAAF (1AA) |
| Kentucky | 24 | at | Southern Miss | 17 | | | SEC |
| Houston | | at | Texas-San Antonio | | | Postponed | AAC |
| Eastern Kentucky | 17 | at | Western Kentucky | 31 | | | OVC (1AA) |
| 9/8/2017 | Alcorn State | 10 | vs | Florida Intl | 17 | | Birmingham AL | vs SWAC (1AA) |
| 9/9/2017 | UAB | 31 | at | Ball State | 51 | | | @ MAC |
| Texas-San Antonio | 17 | at | Baylor | 10 | | | @ B12 |
| Western Kentucky | 7 | at | Illinois | 20 | | | @ B10 |
| UNC-Charlotte | 7 | at | Kansas State | 55 | | | @ B12 |
| Mississippi State | 57 | at | Louisiana Tech | 21 | | | SEC |
| Old Dominion | 17 | at | Massachusetts | 7 | | | @ Ind |
| Marshall | 20 | at | North Carolina State | 37 | | | @ ACC |
| North Texas | 32 | at | SMU | 54 | | | @ AAC |
| Southern | 0 | at | Southern Miss | 45 | | | SWAC (1AA) |
| Middle Tenn State | 30 | at | Syracuse | 23 | | | @ ACC |
| Rice | 31 | at | UTEP | 14 | | | |
| Florida Atlantic | 14 | at | Wisconsin | 31 | | | @ B10 |
| 9/15/2017 | Arizona | 63 | at | UTEP | 16 | | | P12 |
| 9/16/2017 | Coastal Carolina | 23 | at | UAB | 30 | | | SBC |
| Bethune-Cookman | 0 | at | Florida Atlantic | 45 | | | MEAC (1AA) |
| Rice | 3 | at | Houston | 38 | | | @ AAC |
| Florida Intl | | vs | Indiana | | | Cancelled WX | vs B10 |
| North Texas | 14 | at | Iowa | 31 | | | @ B10 |
| Southern Miss | 28 | at | UL Monroe | 17 | | | @ SBC |
| Kent State | 0 | at | Marshall | 21 | | | MAC |
| Middle Tenn State | 3 | at | Minnesota | 34 | | | @ B10 |
| North Carolina | 53 | at | Old Dominion | 23 | | | ACC |
| Southern | 17 | at | Texas-San Antonio | 51 | | | SWAC (1AA) |
| North Carolina A&T | 35 | at | UNC-Charlotte | 31 | | | MEAC (1AA) |
| Louisiana Tech | 23 | at | Western Kentucky | 22 | | | |
| 9/23/2017 | Florida Atlantic | 31 | at | Buffalo | 34 | | | @ MAC |
| Bowling Green | 13 | at | Middle Tenn State | 24 | | | MAC |
| UTEP | 14 | at | New Mexico State | 41 | | | @ SBC |
| UAB | 43 | at | North Texas | 46 | | | |
| Florida Intl | 13 | at | Rice | 7 | | | |
| Louisiana Tech | 16 | at | South Carolina | 17 | | | @ SEC |
| Texas-San Antonio | 44 | at | Texas State | 14 | | | @ SBC |
| Georgia State | 28 | at | UNC-Charlotte | 0 | | | SBC |
| Old Dominion | 0 | at | Virginia Tech | 38 | | | @ ACC |
| Ball State | 21 | at | Western Kentucky | 33 | | | MAC |
| 9/30/2017 | UTEP | 21 | at | Army | 35 | | | @ Ind |
| Marshall | 38 | at | Cincinnati | 21 | | | @ AAC |
| Middle Tenn State | 20 | at | Florida Atlantic | 38 | | | |
| UNC-Charlotte | 29 | at | Florida Intl | 30 | | | |
| South Alabama | 16 | at | Louisiana Tech | 34 | | | SBC |
| Rice | 10 | at | Pittsburgh | 42 | | | @ ACC |
| North Texas | 43 | at | Southern Miss | 28 | | | |
| 10/7/2017 | Louisiana Tech | 22 | at | UAB | 23 | | | |
| Florida Intl | 17 | at | Middle Tenn State | 37 | | | |
| Florida Atlantic | 58 | at | Old Dominion | 28 | | | |
| Army | 49 | at | Rice | 12 | | | Ind |
| Southern Miss | 31 | at | Texas-San Antonio | 29 | | | |
| Marshall | 14 | at | UNC-Charlotte | 3 | | | |
| Western Kentucky | 15 | at | UTEP | 14 | | | |
| 10/14/2017 | Middle Tenn State | 23 | at | UAB | 25 | | | |
| Tulane | 10 | at | Florida Intl | 23 | | | AAC |
| Old Dominion | 3 | at | Marshall | 35 | | | |
| Texas-San Antonio | 26 | at | North Texas | 29 | | | |
| UTEP | 0 | at | Southern Miss | 24 | | | |
| UNC-Charlotte | 14 | at | Western Kentucky | 45 | | | |
| 10/20/2017 | Marshall | 38 | at | Middle Tenn State | 10 | | | |
| Western Kentucky | 35 | at | Old Dominion | 31 | | | |
| 10/21/2017 | North Texas | 31 | at | Florida Atlantic | 69 | | | |
| Southern Miss | 34 | at | Louisiana Tech | 27 | 2OT | | |
| Rice | 7 | at | Texas-San Antonio | 20 | | | |
| UAB | 24 | at | UNC-Charlotte | 25 | OT | | |
| 10/28/2017 | Florida Intl | 41 | at | Marshall | 30 | | | |
| Old Dominion | 38 | at | North Texas | 45 | | | |
| Louisiana Tech | 42 | at | Rice | 28 | | | |
| UAB | 30 | at | Southern Miss | 12 | | | |
| Texas-San Antonio | 31 | at | UTEP | 14 | | | |
| Florida Atlantic | 42 | at | Western Kentucky | 28 | | | |
| 11/3/2017 | Marshall | 25 | at | Florida Atlantic | 30 | | | |
| 11/4/2017 | Rice | 21 | at | UAB | 52 | | | |
| Texas-San Antonio | 7 | at | Florida Intl | 14 | | | |
| North Texas | 24 | at | Louisiana Tech | 23 | | | |
| UTEP | 3 | at | Middle Tenn State | 30 | | | |
| UNC-Charlotte | 0 | at | Old Dominion | 6 | | | |
| Southern Miss | 10 | at | Tennessee | 24 | | | @ SEC |
| Western Kentucky | 17 | at | Vanderbilt | 31 | | | @ SEC |
| 11/11/2017 | Old Dominion | 37 | at | Florida Intl | 30 | | | |
| Florida Atlantic | 48 | at | Louisiana Tech | 23 | | | |
| Western Kentucky | 23 | at | Marshall | 30 | | | |
| UTEP | 10 | at | North Texas | 45 | | | |
| Southern Miss | 43 | at | Rice | 34 | | | |
| UAB | 24 | at | Texas-San Antonio | 19 | | | |
| Middle Tenn State | 35 | at | UNC-Charlotte | 21 | | | |
| 11/17/2017 | Middle Tenn State | 38 | at | Western Kentucky | 41 | | | |
| 11/18/2017 | UAB | 7 | at | Florida | 36 | | | @ SEC |
| Florida Intl | 24 | at | Florida Atlantic | 52 | | | |
| Army | 49 | at | North Texas | 52 | | | Ind |
| Rice | 21 | at | Old Dominion | 24 | | | |
| UNC-Charlotte | 21 | at | Southern Miss | 66 | | | |
| Marshall | 7 | at | Texas-San Antonio | 9 | | | |
| Louisiana Tech | 42 | at | UTEP | 21 | | | |
| 11/24/2017 | Western Kentucky | 17 | at | Florida Intl | 41 | | | |
| 11/25/2017 | UTEP | 7 | at | UAB | 28 | | | |
| Texas-San Antonio | 6 | at | Louisiana Tech | 20 | | | |
| Southern Miss | 28 | at | Marshall | 27 | | | |
| Old Dominion | 10 | at | Middle Tenn State | 41 | | | |
| North Texas | 30 | at | Rice | 14 | | | |
| Florida Atlantic | 31 | at | UNC-Charlotte | 12 | | | |
| 12/2/2017 | North Texas | 17 | at | Florida Atlantic | 41 | | CUSA Championship | |
| Massachusetts | 45 | at | Florida Intl | 63 | | | Ind |
| 12/16/2017 | Middle Tenn State | 35 | vs | Arkansas State | 30 | | Camelia Bowl (Montgomery AL) | vs SBC |
| Marshall | 31 | vs | Colorado State | 28 | | New Mexico Bowl (Albuquerque NM) | vs MW |
| Western Kentucky | 17 | vs | Georgia State | 27 | | Cure Bowl (Orlando FL) | vs SBC |
| Troy | 50 | vs | North Texas | 30 | | New Orleans Bowl (New Orleans LA) | vs SBC |
| 12/19/2017 | Akron | 3 | vs | Florida Atlantic | 50 | | Boca Raton Bowl (Boca Raton FL) | vs MAC |
| 12/20/2017 | Louisiana Tech | 51 | vs | SMU | 10 | | Frisco Bowl (Frisco TX) | vs AAC |
| 12/21/2017 | Temple | 28 | vs | Florida Intl | 3 | | Gasparilla Bowl (Saint Petersburg FL) | vs AAC |
| 12/22/2017 | UAB | 6 | vs | Ohio | 41 | | Bahamas Bowl (Nassau NP) | vs MAC |
| 12/27/2017 | Southern Miss | 13 | vs | Florida State | 42 | | Independence Bowl (Shreveport LA) | vs ACC |